Tetrahedron letters

Application of the intramolecular aza-Wittig reaction to the synthesis of pyrido [2, 3-d] pyrimidines

J Chan, M Faul

Index: Chan, Johann; Faul, Margaret Tetrahedron Letters, 2006 , vol. 47, # 20 p. 3361 - 3363

Full Text: HTML

Citation Number: 23

Abstract

Pyrido [2, 3-d] pyrimidines are synthesized in a two-step procedure from amides and tetrazolo [1, 5-a] pyridine-8-carbonyl chloride. Reaction of the crude imides with triphenylphosphine effects an intramolecular aza-Wittig reaction to afford a variety of substituted pyrido [2, 3-d] pyrimidines in good to moderate yields (30–76%).