Synthesis

Synthesis of carbohydrate-conjugated dT analogues using 'click chemistry'

X Jin, R Yang, P Jin, Q Xiao, Y Ju

Index: Jin, Xuanye; Yang, Ruchun; Jin, Peiyuan; Xiao, Qiang; Ju, Yong Synthesis, 2007 , # 19 p. 2967 - 2972

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Citation Number: 13

Abstract

Abstract A new type furo [2, 3-d] pyrimidine nucleoside conjugated with various carbohydrates was synthesized using Sonogashira coupling and 'click chemistry'. In the subsequent deprotection of the 4-toluoyl and acetyl groups with catalytic sodium methoxide in methanol, the furo [2, 3-d] pyrimidine rearranged to an opened ketone-type structure. Their structures were confirmed on the basis of spectroscopy.

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