Tetrahedron letters

An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles

…, WI Iwema-Bakker, JAJ den Hartog, J van Schaik…

Index: van den Hoogenband, Adri; Lange, Jos H.M.; Iwema-Bakker, Wouter I.; den Hartog, Jack A.J.; van Schaik, Jord; Feenstra, Rolf W.; Terpstra, Jan Willem Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4361 - 4364

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Citation Number: 14

Abstract

An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2, 6- dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with a (hetero) arylboronic acid in a one-pot reaction.

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