Synthesis and antibacterial activity of 1-(arylamino)-1H-pyrroles and 4-(1H-pyrrol-1-ylimino)-2, 5-cyclohexadienes

RE Johnson, AE Soria, JR O'Connor…

Index: Johnson; Soria; O'Connor; Dobson Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1314 - 1319

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Citation Number: 12

Abstract

-N- syn-27-stimulation of cell-mediated immunity.'This unique compound is one of a series of structurally related 1-(ary1amino)-1H-pyrrol-l-amines and 4-(1H-pyrrol-l-yl-imino)-2, 5-~ yclohexadienes that were investigated for in vitro antibacterial activity and in vivo antitubercular activity. The purpose of this paper is to describe the syn-thesis of this series of compounds and to relate some of the structural requirements necessary for their ...