Lewis acid-assisted olefin cross-metathesis reaction: an efficient approach for the synthesis of glycosidic-pyrroloquinolinone based novel building blocks of …

L Nagarapu, HK Gaikwad, R Bantu, SR Manikonda…

Index: Nagarapu, Lingaiah; Gaikwad, Hanmant K.; Bantu, Rajashaker; Ganesh Kumar; Pombala, Sujitha Tetrahedron Letters, 2012 , vol. 53, # 10 p. 1287 - 1291

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Citation Number: 9

Abstract

A series of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin (2a– g) were synthesized via Lewis acid-assisted olefin cross-metathesis reaction using Ti (OiPr) 4 30mol% and 10mol% of Grubb's second generation catalyst with good to excellent yields. Most of these compounds exhibited significant growth inhibitory effects on all the tested cancer cell lines and three compounds (2c, 2d and 2e) showed potent cytotoxic activity.

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