Efficacious and orally bioavailable thrombin inhibitors based on a 2, 5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl [(5- …

K Lee, CW Park, WH Jung, HD Park…

Index: Journal of Medicinal Chemistry, , vol. 46, # 17 p. 3612 - 3622

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Citation Number: 31

Abstract

... Journal of Medicinal Chemistry. ... prophylaxis of venous and arterial thrombosis. 1. Small-molecule inhibitors of thrombin have been of considerable interest to medicinal chemists over the past decade. 2 Some years ago, we ...

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