Synthesis of peptides containing hydroxyamino acids by the mixed anhydride method without protecting the hydroxyl functions

M Ueki, T Inazu

Index: Ueki, Masaaki; Inazu, Toshiyuki Chemistry Letters, 1982 , p. 45 - 48

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Citation Number: 32

Abstract

Dimethylphosphinothioyl (Mpt) mixed anhydrides of N-protected amino acids were found to be isolatably stable and useful for the synthesis of hydroxyamino acid containing peptides without protecting the side-chain hydroxyl functions. They were applied for the solid phase synthesis of an enkephalin analog extended at C-terminal.