Synthesis and structure–activity relationships of novel arylalkyl 4-benzyl piperazine derivatives as σ site selective ligands

S Younes, Y Labssita, G Baziard-Mouysset…

Index: Younes, Salome; Labssita, Youssef; Baziard-Mouysset, Genevieve; Payard, Marc; Rettori, Marie-Claire; Renard, Pierre; Pfeiffer, Bruno; Caignard, Daniel-Henri European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 107 - 121

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Citation Number: 28

Abstract

Continuing our previous work that established that some chromones substitued by an aryl alkyl piperazino alkyl side chain are potent and selective sigma ligands and could be interesting in the treatment of psychosis, we synthesized 60 new compounds, replacing the chromone moiety by various cyclic systems. Many derivatives bind to the sigma sites in the nanomolar range and are generally selective in comparison with 5HT1A and the D2 ...