Bioorganic & medicinal chemistry

Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses

F Xue, X Luo, C Ye, W Ye, Y Wang

Index: Xue, Fei; Luo, Xianjin; Ye, Chenghao; Ye, Weidong; Wang, Yue Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2641 - 2649

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Citation Number: 37

Abstract

Abstract A series of novel benzimidazole derivatives were designed, synthesized, and evaluated for their activities against four kinds of enteroviruses, that is, Coxsackie virus A16, B3, B6 and Enterovirus 71 in VERO cells. Strong activities against enterovirus replication and low cytotoxicities were observed in these benzimidazoles generally. The most promising compound was (l)-2-(pyridin-2-yl)-N-(2-(4-nitrophenyl) pentan-3-yl)-1H- ...

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