Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone

…, FM Konzelmann, DL Pruess, C Chen Wei

Index: Albrecht; Beskid; Christenson; Deitcher; Georgopapadakou; Keith; Konzelmann; Pruess; Chung Chen Wei Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 400 - 407

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Citation Number: 56

Abstract

We have previously reported that linking quinolones to the cephalosporin 3'-position through an ester bond, a carbamate function, or a bond through a quaternary nitrogen produced cephalosporins with a dual mode of antibacterial action. We now describe a new class of dual-action cephalosporins, with greater chemical stability than those previously reported, in which the basic nitrogen of ciprofloxacin is bonded directly to the 3'-cephalosporin ...