Effective reductive amination of carbonyl compounds with hydrogen catalyzed by iridium complex in organic solvent and in ionic liquid

D Imao, S Fujihara, T Yamamoto, T Ohta, Y Ito

Index: Imao, Daisuke; Fujihara, Shoichiro; Yamamoto, Takeshi; Ohta, Tetsuo; Ito, Yoshihiko Tetrahedron, 2005 , vol. 61, # 29 p. 6988 - 6992

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Citation Number: 70

Abstract

The direct reductive amination (DRA) of carbonyl compounds with amines has been achieved using homogenous iridium catalyst and gaseous hydrogen. It appeared that the cationic iridium catalyst,[Ir (cod) 2] BF4, without any other ligands was sufficient for the reaction. For the DRA of the ketone substrates, an ionic liquid,[Bmim] BF4, was found to be superior to the other organic solvent used. Especially, the counter anion of the ionic liquid ...