Synthetic communications

PREPARATION OF 1, 7-DISUBSTITUTED-1, 2, 3, 4-TETRAHYDROISOQUINOLINES

JP Heer, JD Harling, M Thompson

Index: Heer, Jag P.; Harling, John D.; Thompson, Mervyn Synthetic Communications, 2002 , vol. 32, # 16 p. 2555 - 2563

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Citation Number: 8

Abstract

ABSTRACT A simple procedure for the preparation of 1, 7-disubstituted-1, 2, 3, 4- tetrahydroisoquinolines from 3, 4-dihydroisoquinoline (2) is presented. This strategy overcomes the limitation of cyclisation approaches which generally require electron rich ring systems. A variety of 1-substituents has been incorporated using the appropriate organometallic or activated methylene nucleophile to prepare both electron rich (7a–f) ...

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