(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure- …

…, M Tran, HB Niznik, HC Guan, P Seeman…

Index: Baindur; Tran; Niznik; Guan; Seeman; Neumeyer Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 67 - 72

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Citation Number: 15

Abstract

DA receptor. 7, 8-Dihydroxy-l-phenyl-2, 3, 4, 5-tetrahydro-lH-3-benzazepine (SKF 38393) and its 6-halo analogues are potent and selective D1 receptor agonists. Recently, the 3-allyl derivatives of SKF 38393 and its analogues were described as selective D1 agonists with higher D1 efficacy and CNS potency. In order to extend these results to compounds in the 7- halo-8-hydroxy-substituted antagonist series, we have synthesized and pharmacologically ...