Tetrahedron letters

A sequential electrochemical Oxidation-olefin metathesis strategy for the construction of bicyclic lactam based peptidomimetics

LM Beal, KD Moeller

Index: Beal, Laura M.; Moeller, Kevin D. Tetrahedron Letters, 1998 , vol. 39, # 26 p. 4639 - 4642

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Citation Number: 34

Abstract

A sequential electrochemical amide oxidation-ring closing olefin metathesis sequence has been used to overcome problems associated with the synthesis of seven-membered ring lactam containing bicyclic peptidomimetics. The synthesis of several previously unavailable bicyclic lactam building blocks for constructing constrained thyroliberin analogs is described.