Synthesis and structure–activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives

KY Chang, SH Kim, G Nam, JH Seo, JH Kim…

Index: Chang, Kwan Young; Kim, Sung Hoon; Nam, Ghilsoo; Seo, Jae Hong; Kim, Joong Hyup; Ha, Deok-Chan Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1211 - 1214

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Citation Number: 23

Abstract

Since first launching ceftazidime to the market as a kind of pyridinium cephalosporin, many efforts have been dedicated to develop quaternary ammonium cephalosporin with broad spectrum against Gram-positive and Gram-negative microorganisms and to overcome the multidrug-resistance. 1, 2 and 3 Representative ceftadizime have a tendency to be mainly used to treat opportunistic infection with Pseudomonas aeruginosa strains, meanwhile ...