Reaction of 2-nitrobenzaldehydes with diethyl (diethoxyphosphinyl) succinate: a new synthesis of quinoline-2, 3-dicarboxylic acid esters via their N-oxides
SB Kadin, CH Lamphere
Index: Kadin, Saul B.; Lamphere, Charles H. Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4999 - 5000
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Citation Number: 9
Abstract
The synthesis of quinoline-2, 3-dicarboxylic acid derivatives can be accomplished by the Friedlander reaction of 2-aminobenzaldehydes with diethyl oxaloacetate112 or by an analogous reaction that utilizes the same aldehydes and acetylenedicarboxylic acid ester^.^ However, the difficulties encountered in preparing and storing 2-aminobenzaldehydes have severely limited the application of these synthetic procedures.
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