Oligomeric cholates: amphiphilic foldamers with nanometer-sized hydrophilic cavities

Y Zhao, Z Zhong

Index: Zhao, Yan; Zhong, Zhenqi Journal of the American Chemical Society, 2005 , vol. 127, # 50 p. 17894 - 17901

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Citation Number: 105

Abstract

The hydroxyl at the C-3 of cholic acid was converted to an amino group, and the resulting amino-functionalized cholic acid was used as a monomer to prepare amide-linked oligomeric cholates. These cholate oligomers fold into helical structures with nanometer- sized hydrophilic internal cavities in solvent mixtures consisting of mostly nonpolar solvents such as carbon tetrachloride or ethyl acetate/hexane and 2-5% of a polar solvent such as ...