Efficient synthesis of 2, 5-diketopiperazines using microwave assisted heating

M Tullberg, M Grøtli, K Luthman

Index: Tullberg, Marcus; Grotli, Morten; Luthman, Kristina Tetrahedron, 2006 , vol. 62, # 31 p. 7484 - 7491

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Citation Number: 59

Abstract

In this study a general, efficient and environmentally benign solution phase synthesis of 2, 5- diketopiperazines (DKPs) using microwave assisted heating in water is described. A series of 11 structurally different DKPs have been synthesized from dipeptide methyl esters. A range of common laboratory solvents have been tested as well as different reaction times and temperatures. Both classic thermal and microwave assisted heating have been ...