Synthesis of arylmethylureas and the influence of structure on their antispasmodic activity

…, LG Tignibidina, VD Filimonov, VK Gorshkova…

Index: Bakibaev, A. A.; Tignibidina, L. G.; Filimonov, V. D.; Gorshkova, V. K.; Saratikov, A. S.; et al. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 5 p. 296 - 301 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 5 p. 31 - 35

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Citation Number: 3

Abstract

We earlier determined the quantitative relationship between the antispasmodic activity, structure, and ZaCNMR spectra for series of benzhydrylureas [4]. In the development of these studies we synthesized 30 derivatives of arylmethylurea, determined their antispasmodic activity, and measured their chemical shifts in the IHNMR and 13CNMR spectra, and also carried out a search for a quantitative relationship between activity, ...