Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-lactamase fusion protein

…, NO Siemers, GM Dubowchik, PD Senter

Index: Vrudhula, Vivekananda M.; Kerr, David E.; Siemers, Nathan O.; Dubowchik, Gene M.; Senter, Peter D. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 539 - 542

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Citation Number: 41

Abstract

Paclitaxel conjugates of 7-phenylacetamidocephalosporanic acid were prepared as prodrugs for site specific activation by targeted β-lactamase. Immunologically specific activation of the prodrug 5 containing 3, 3-dimethyl-4-amino-butyric acid as linker in combination with the fusion protein L-49-sFv-β-lactamase was demonstrated in vitro on 3677 melanoma cells.