Chalcone inhibition of anthracycline secondary alcohol metabolite formation in rabbit and human heart cytosol

A Silvestrini, E Meucci, A Vitali, B Giardina…

Index: Botta, Bruno; Delle Monache, Giuliano; De Rosa, Maria Cristina; Scurria, Rosalba; Vitali, Alberto; Vinciguerra, Vittorio; Menendez, Pilar; Misiti, Domenico Heterocycles, 1996 , vol. 43, # 7 p. 1415 - 1421

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Citation Number: 14

Abstract

Antineoplastic therapy with anthracyclines like doxorubicin (DOX) and daunorubicin (DNR) is limited by the possible development of a dose-related cardiomyopathy. Secondary alcohol metabolites like doxorubicinol (DOXol) and daunorubicinol (DNRol), formed by cytoplasmic

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