Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy [1, 4-bis (phosphonomethoxy)] butan-2-yl} derivatives of purines

S Vrbková, M Dračínský, A Holý

Index: Vrbkova, Silvie; Dracinsky, Martin; Holy, Antonin Tetrahedron Asymmetry, 2007 , vol. 18, # 18 p. 2233 - 2247

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Citation Number: 17

Abstract

We report herein a general method for the synthesis of new types of chiral acyclic nucleoside four-carbon bisphosphonates. The alkylation of 2-amino-6-chloropurine and adenine was performed with (2S, 3S)-or (2R, 3R)-1, 4-[bis (diisopropoxyphosphoryl) ...