β??Turn Analogues in Model αβ??Hybrid Peptides: Structural Characterization of Peptides Containing β2, 2Ac6c and β3, 3Ac6c Residues

…, S Raghothama, N Shamala, P Balaram

Index: Basuroy, Krishnayan; Rajagopal, Appavu; Raghothama, Srinivasarao; Shamala, Narayanaswamy; Balaram, Padmanabhan Chemistry - An Asian Journal, 2012 , vol. 7, # 7 p. 1671 - 1678

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Citation Number: 23

Abstract

Abstract The effect of gem-dialkyl substituents on the backbone conformations of β-amino acid residues in peptides has been investigated by using four model peptides: Boc-Xxx-β 2, 2 Ac 6 c (1-aminomethylcyclohexanecarboxylic acid)-NHMe (Xxx= Leu (1), Phe (2); Boc= tert- butyloxycarbonyl) and Boc-Xxx-β 3, 3 Ac 6 c (1-aminocyclohexaneacetic acid)-NHMe (Xxx= Leu (3), Phe (4)). Tetrasubstituted carbon atoms restrict the ranges of stereochemically ...

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