Design, syntheses, and characterization of pharmacophore based chemokine receptor CCR5 antagonists as anti prostate cancer agents
…, SA Zaidi, Z Zhang, G Li, AC Richardson…
Index: Arnatt, Christopher K.; Zaidi, Saheem A.; Zhang, Zhu; Li, Guo; Richardson, Amanda C.; Ware, Joy L.; Zhang, Yan European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 647 - 658
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Citation Number: 14
Abstract
Abstract Accumulating evidence has shown multiple roles that chemokine receptor CCR5 may play to promote the progression of several types of cancer. The mechanism of such promotion is believed to involve chronic inflammation that creates a microenvironment which enhances tumor survival. Therefore, blocking CCR5 function with an antagonist may provide a novel treatment of cancers such as prostate cancer. Currently, several CCR5 ...
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