Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand

…, J Maksimoska, H Bregman, DS Williams…

Index: Pagano, Nicholas; Maksimoska, Jasna; Bregman, Howard; Williams, Douglas S.; Webster, Richard D.; Xue, Feng; Meggers, Eric Organic and Biomolecular Chemistry, 2007 , vol. 5, # 8 p. 1218 - 1227

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Citation Number: 84

Abstract

A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a ...