A new strategy for the synthesis of crucigasterin A, and cytotoxic activity of this compound and its related analogues

…, PR Reddy, B Das, CG Kumar, P Sujitha

Index: Kumar, Jayprakash Narayan; Reddy, Parigi Raghavendar; Das, Biswanath; Kumar, C. Ganesh; Sujitha, Pombala Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5192 - 5194

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Citation Number: 3

Abstract

Abstract Stereoselective total synthesis of bioactive marine natural product crucigasterin A has been accomplished from commercially available and inexpensive l-(−)-malic acid as a starting material. Julia olefination and chelation controlled Grignard additions are the key steps involved in the present synthesis. Cytotoxic properties of crucigasterin A and its related analogues crucigasterins B and D have been evaluated. Crucigasterin A showed ...

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