New synthesis of thiol esters

S Yamada, Y Yokoyama, T Shioiri

Index: Yamada,S. et al. Journal of Organic Chemistry, 1974 , vol. 39, # 22 p. 3302 - 3303

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Citation Number: 66

Abstract

Sir: In spite of its potential importance there is still no generalized method for the direct preparation of thiol es- ters from carboxylic acids and thio1s.l We now wish to re- port this transformation, which involves treatment of a car- boxylic acid and a thiol with diethyl phosphorocyanidate (DEPC)2 or diphenyl phosphorazidate (DPPA)3 in the presence of triethylamine in dimethylformamide solution. While optimum reaction conditions have yet to be estab- lished, the results ...