Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1, 2, 4-triazol-4-yl] benzophenones, a novel class of annulated peptidoaminobenzophenones

K Hirai, T Fujishita, T Ishiba, H Sugimoto…

Index: Hirai; Fujishita; Ishiba; Sugimoto; Matsutani; Tsukinoki; Hirose Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1466 - 1473

Full Text: HTML

Citation Number: 26

Abstract

A series of the title compounds was prepared via condensation of the 3-(aminomethyl) triazolylbenzophenone (5) with N-protected amino acids, followed by deprotection, amination of the 3-[(chloroacetamido) methyl] triazolyl-benzophenone (6a, b), or reduction of the relevant azide derivative (6c). Some of the title compounds were also derived directly from the quinazolines 3 or 4 by acid-induced rearrangement, followed by deprotection. ...