Synthesis and anticonvulsant activity of 3H??imidazo [4, 5??c]??pyridazine, 1H??imidazo [4, 5??d] pyridazine and 1H??benzimidazole analogues of 9??(2??fluorobenzyl)??6?? …
…, JB Thompson, VL Styles, FE Soroko…
Index: Kelley; Thompson; Styles; Soroko; Cooper Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 5 p. 1423 - 1428
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Citation Number: 16
Abstract
Abstract The 3H-imidazo [4, 5-c] pyridazine, 1H-imidazo [4, 5-d] pyridazine, and 1H- benzimidazole analogues of the potent anticonvulsant purine 9-(2-fluorobenzyl)-6- methylamino-9H-purine (1, 78U79) were synthesized and tested for anticonvulsant activity. The 3H-imidazo [4, 5-c] pyridazines 8 and 9 were prepared in five stages from 3, 4, 5- trichloropyridazine (2). The 1H-imidazolo [4, 5-d] pyridazine 15 was synthesized in four ...
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