Synthesis and some transformations of γ-(p-fluorophenyl)-γ-(2-furyl) propylamine

NS Arutyunyan, LA Akopyan, GM Snkhchyan…

Index: Arutyunyan; Akopyan; Snkhchyan; Papoyan; Panosyan; Gevorgyan Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 4 p. 440 - 445

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Abstract

Abstract Ethyl α-cyano-β-(p-fluorophenyl)-β-(2-furyl) propionate was obtained by the condensation of ethyl α-cyano-β-(2-furyl) acrylate with p-fluorophenylmagnesium bromide. Its deethoxycarbonylation led to β-(p-fluorophenyl)-β-(2-furyl) propionitrile. Reduction of the nitrile with lithium aluminum hydride gave γ-(p-fluorophenyl)-γ-(2-furyl) propylamine. Some transformations of the latter were studied.

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