Semisynthetic penicillins

…, YZ Ter-Zakharyan, ÉV Kazaryan, VS Sakanyan

Index: Mndzhoyan, Sh. L.; Marukhyan, N. D.; Ter-Zakharyan, Yu. Z.; Kazaryan, E. V.; Sakanyan, V. S. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 12 p. 864 - 867 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 12 p. 37 - 41

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Abstract

The trisubstituted acetic acids used as starting materials were prepared by condensing guaiacol withthe appropriate a, a-dialkylbromoacetic acid [1]. The structures of the products were confirmed by elemental analysis and physical data; IR and NMR spectra confirmed the presence of a carboxyl carbonyl group and an ether linkage (Table 1).