Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents

AKM Hayallah, AA Talhouni, AAMA Alim

Index: Hayallah, Alaa M.; Talhouni, Ahmad A.; Abdel Alim, Abdel Alim M. Archives of Pharmacal Research, 2012 , vol. 35, # 8 p. 1355 - 1368

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Citation Number: 7

Abstract

Abstract Theophylline derivatives have long been recognized as potent bronchodilators for the relief of acute asthma. Recently, it was found that bacterial infection has a role in asthma pathogenesis. The present work involves the design and synthesis of 8-substituted theophylline derivatives as bronchodilators and antibacterial agents. The chemical structures of these compounds were elucidated by IR, 1 H-NMR, mass spectrometry, and ...