A highly efficient approach for the synthesis of cationic lipid DOSPA
Y Li, RJ Debs, TD Heath
Index: Li, Yanhong; Debs, Robert J.; Heath, Timothy D. Synlett, 2006 , # 14 p. 2284 - 2286
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Abstract
Abstract A highly efficient strategy has been developed for the synthesis of the cationic lipid, N-[2-({2, 5-bis [(3-aminopropyl) amino]-1-oxopentyl} amino) ethyl]-N, N-dimethyl-2, 3-bis [(1- oxo-9-octadecenyl) oxy] salt with hydrogen chloride (DOSPA). It involves the linkage of a cationic head group and a hydrophobic moiety in the presence of the standard coupling reagents.
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[Ewert, Kai K.; Evans, Heather M.; Zidovska, Alexandra; Bouxsein, Nathan F.; Ahmad, Ayesha; Safinya, Cyrus R. Journal of the American Chemical Society, 2006 , vol. 128, # 12 p. 3998 - 4006]