Design, synthesis, and structure–activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors

LJ Lombardo, A Camuso, J Clark, K Fager…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 7 p. 1895 - 1899

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Citation Number: 28

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Amide analogues did not suffer from chemical instability in the assay media and possessed biochemical potencies similar to 7e, but were considerably less potent in the cellular reversion assay and were not pursued further (data not ...