Tetrahedron Letters

1, 3-Dipolar cycloaddition of diazoacetate compounds to terminal alkynes promoted by Zn (OTf) 2: an efficient way to the preparation of pyrazoles

S He, L Chen, YN Niu, LY Wu, YM Liang

Index: He, Sheng; Chen, Li; Niu, Yan-Ning; Wu, Lu-Yong; Liang, Yong-Min Tetrahedron Letters, 2009 , vol. 50, # 20 p. 2443 - 2445

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Citation Number: 27

Abstract

Pyrazole derivatives are known as an important class of heterocycles which display an ample spectrum of biological activities and are widely employed as anti-tumor, anti-inflammatory, anti-microbial, and anti-psychotic agents. 1 The most widely used method for their synthesis is the reaction between 1,3-dicarbonyl compounds and hydrazines, 2 and 3 the harsh reaction conditions or the multistep sequences usually required to access the starting materials ...