Synthetic routes to nucieoside analogs of N-substituted 1-oxa-4-azacyclohexanes and 1-thia-4-azacyclohexanes. 13C nuclear magnetic resonance spectra of six- …

BM Pinto, DM Vyas, WA Szarek

Index: Pinto,B.M. et al. Canadian Journal of Chemistry, 1977 , vol. 55, p. 937 - 948

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Citation Number: 12

Abstract

Nucleoside analogs, namely 6-chloro-9-(4-benzoyl-1-oxa-4-azacyclohexan-2-yl)-9 H-purine 6 and 6-chloro-9-(4-benzoyl-1-thia-4-azacyclohexan-2-yl)-9 H-purine 7, were obtained by treatment of 4-benzoyl-2-hydroxy-1-oxa-4-azacyclohexane 13 and 4-benzoyl-2-hydroxy-1- thia-4-azacyclohexane 18, respectively, with 6-chloropurine, methyldiphenylphosphine, and diethyl azodicarboxylate in refluxing tetrahydrofuran. Compounds 13 and 18 were ...