Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds

E Kato, J Kawabata

Index: Kato, Eisuke; Kawabata, Jun Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4333 - 4336

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Citation Number: 14

Abstract

Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and several derivatives to apply for the structure–activity relationship ...