Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3, 9-Difluoro-12, 13-dihydro-13-[6- …

BN Balasubramanian, DR St. Laurent…

Index: Journal of Medicinal Chemistry, , vol. 47, # 7 p. 1609 - 1612

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Citation Number: 28

Abstract

... Journal of Medicinal Chemistry. ... The indolocarbazole nucleus and its corresponding thio and oxo analogues were efficiently assembled via the chemistry described in Schemes 1 and 2. Stepwise addition of an appropriately substituted (eg, 19−26, 31−33, Table 1) indole ...

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