Tetrahedron Letters

Iron-catalyzed cascade reaction of ynone with o-aminoaryl compounds: a Michael addition–cyclization approach to 3-carbonyl quinolines

H Li, X Xu, J Yang, X Xie, H Huang, Y Li

Index: Li, Hongfeng; Xu, Xiaolei; Yang, Jingyu; Xie, Xin; Huang, He; Li, Yanzhong Tetrahedron Letters, 2011 , vol. 52, # 4 p. 530 - 533

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Citation Number: 31

Abstract

An efficient iron-catalyzed cascade Michael addition–cyclization of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones, and o-aminobenzyl alcohols with ynones for the synthesis of 3-carbonyl quinolines is reported. The reactions proceed to afford 3-carbonyl quinoline derivatives with or without substituent at the C-4 position in good to high yields using Iron (III) chloride hexahydrate as the catalyst in the air.

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