Bioorganic & medicinal chemistry letters

Novel quinazoline–quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities

Z Ma, Y Hano, T Nomura, Y Chen

Index: Ma, Zhongze; Hano, Yoshio; Nomura, Taro; Chen, Yingjie Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1193 - 1196

Full Text: HTML

Citation Number: 108

Abstract

Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H (quinazolino-4-one)] quinoline (7) were synthesized. The new analogues, along with four natural quinazoline–quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC50 1.8–40.0 μg/mL) and DNA topoisomerase II inhibition at a concentration of 25 μM.

Related Articles:

Iron-catalyzed cascade reaction of ynone with o-aminoaryl compounds: a Michael addition–cyclization approach to 3-carbonyl quinolines

[Li, Hongfeng; Xu, Xiaolei; Yang, Jingyu; Xie, Xin; Huang, He; Li, Yanzhong Tetrahedron Letters, 2011 , vol. 52, # 4 p. 530 - 533]

Epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors

[Mai, Antonello; Rotili, Dante; Tarantino, Domenico; Ornaghi, Prisca; Tosi, Federica; Vicidomini, Caterina; Sbardella, Gianluca; Nebbioso, Angela; Miceli, Marco; Altucci, Lucia; Filetici, Patrizia Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6897 - 6907]

More Articles...