Tetrahedron

One-pot approach to the synthesis of novel 12H-chromeno [2′, 3′: 4, 5] imidazo [1, 2-a] pyridines in aqueous media

MF Proença, M Costa

Index: Proenca, M. Fernanda; Costa, Marta Tetrahedron, 2010 , vol. 66, # 25 p. 4542 - 4550

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Citation Number: 11

Abstract

The chromeno-imidazo [1, 2-a] pyridine scaffold was generated in an one pot condensation/ cyclization reaction involving a salicylaldehyde and 1-(cyanomethyl) pyridinium chloride, in aqueous sodium carbonate solution. These novel compounds were isolated in 47–71% yield. The reaction pathway was followed by 1H NMR spectroscopy allowing a clear understanding of the side reactions involved in the process. Different mono-substituted ...