Synthesis of new antimicrobial pyrrolo [2, 1-a] isoquinolin-3-ones

L Moreno, J Párraga, A Galán, N Cabedo…

Index: Moreno, Laura; Parraga, Javier; Galan, Abraham; Cortes, Diego; Cabedo, Nuria; Primo, Jaime Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 22 p. 6589 - 6597,9

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Citation Number: 16

Abstract

The attractive structure of the pyrroloisoquinoline moiety, together with its potential antimicrobial activity, encouraged us to prepare six 8-substituted and seven 8, 9- disubstituted-1, 2, 3, 5, 6, 10b-hexahydropyrrolo [2, 1-a] isoquinolin-3-ones in a few steps with good yields. We applied a convenient methodology via double intramolecular cyclization conducted by a Bischler-Napieralski cyclodehydration-imine reduction ...

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