Tetrahedron

Efficient synthesis of 2, 4-disubstituted thiazoles using ionic liquid under ambient conditions: a practical approach towards the synthesis of Fanetizole

TM Potewar, SA Ingale, KV Srinivasan

Index: Potewar, Taterao M.; Ingale, Sachin A.; Srinivasan, Kumar V. Tetrahedron, 2007 , vol. 63, # 45 p. 11066 - 11069

Full Text: HTML

Citation Number: 87

Abstract

A highly efficient and rapid synthesis of 2-amino-4-arylthiazoles and 2-methyl-4-arylthiazole from α-bromoketone and thiourea/thioamide is described using room temperature ionic liquid at ambient conditions. The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. This protocol is utilized for a commercially feasible synthesis of an anti-inflammatory agent, Fanetizole.

Related Articles:

Scaling up of continuous flow processes with gases using a tube-in-tube reactor: Inline titrations and fanetizole synthesis with ammonia

[Pastre, Julio C.; Browne, Duncan L.; O'Brien, Matthew; Ley, Steven V. Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1183 - 1191]

Efficient Synthesis of 2??Aminothiazoles and Fanetizole in Liquid PEG??400 at Ambient Conditions

[Lin, Pei-Ying; Hou, Rei-Sheu; Wang, Huey-Min; Kang, Iou-Jiun; Chen, Ling-Ching Journal of the Chinese Chemical Society, 2009 , vol. 56, # 3 p. 455 - 458]

More Articles...