Chemical Communications

Palladium-catalysed N-annulation routes to indoles: the synthesis of indoles with sterically demanding N-substituents, including demethylasterriquinone A1

AJ Fletcher, MN Bax, MC Willis

Index: Fletcher, Anthony J.; Bax, Matthew N.; Willis, Michael C. Chemical Communications, 2007 , # 45 p. 4764 - 4766

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Citation Number: 33

Abstract

The majority of indole syntheses involve cyclisation of an acyclic precursor that contains the key N-atom. To adapt these syntheses to the preparation of N-substituted indoles requires that either the precursors must be modified (to include the substituent), or an efficient and selective functionalisation of an indole N–H must be achieved. This is often problematic; for example, syntheses of the simple natural product 1, and related structures, resort to functionalisation of indoline derivatives ...

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