Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid …

CJ Bennett, ST Caldwell, DB McPhail…

Index: Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098

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Citation Number: 82

Abstract

The flavonol myricetin, reacts with oxygen-centred galvinoxyl radicals 28 times faster than d- α-tocopherol (vitamin E), the main lipid-soluble antioxidant in biological membranes. Moreover, each myricetin molecule reduces twice as many such radicals as vitamin E. However, myricetin fails to protect vitamin E-deficient microsomes from lipid peroxidation as assessed by the formation of thiobarbituric acid reactive substances (TBARS). Novel and ...