Tetrahedron Letters

Formylation of amines through catalyst-and solvent-free transamidation reaction

T Lebleu, H Kotsuki, J Maddaluno, J Legros

Index: Lebleu, Thomas; Kotsuki, Hiyoshizo; Maddaluno, Jacques; Legros, Julien Tetrahedron Letters, 2014 , vol. 55, # 2 p. 362 - 364

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Citation Number: 8

Abstract

Abstract The transamidation between formamide and various amines proceeds under heating, without any catalyst nor solvent, providing thus green and neutral conditions for the formylation of primary and secondary amines. The resulting amide product can be directly transformed, in a one pot sequence, into monomethylamine.

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