Synthesis and evaluation of 2-tosylamino and 2-tosyliminopyrimidine derivatives as inhibitors of some leukocyte functions

…, J Lasri, ME González-Rosende, M Akssira…

Index: Fernandez-Ferri, Patricia; Ubeda, Amalia; Guillen, Isabel; Lasri, Jamal; Gonzalez-Rosende, M. Eugenia; Akssira, Mohamed; Sepulveda-Arques, Jose European Journal of Medicinal Chemistry, 2003 , vol. 38, # 3 p. 289 - 296

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Citation Number: 14

Abstract

We have studied the potential anti-inflammatory effects of 20 2-tosylamino and 2- tosyliminopyrimidine new derivatives in human neutrophils. We have evaluated their interference with some leukocyte functions and 5-lipoxygenase activity. All the compounds reduced neutrophil degranulation process at concentrations in the μM range. Besides, compounds with a phenolic substitution inhibited leukotriene B4 biosynthesis in ...