High??Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush??Like Copolymers Produced by ROMP

…, Y Kuramochi, H Matsuoka, H Harada…

Index: Miki, Koji; Kimura, Akinori; Oride, Kazuaki; Kuramochi, Yoshiaki; Matsuoka, Hideki; Harada, Hiroshi; Hiraoka, Masahiro; Ohe, Kouichi Angewandte Chemie - International Edition, 2011 , vol. 50, # 29 p. 6567 - 6570

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Citation Number: 36

Abstract

Optical imaging techniques used to detect malignant tumors by endoscopy or at surgery require near-infrared fluorescence (NIRF) probes containing dyes with high signal-to-noise (S/N) ratios.[1] Along with a high S/N ratio in the near-infrared spectral region, these probes must accumulate specifically in the targeted tumor tissues. Spherical amphiphilic assemblies with diameters of 50–200 nm, such as liposomes, liposomelike assemblies,[2] and ...