Introduction of N??Containing Heterocycles into Pyrazole by Nucleophilic Aromatic Substitution

MS Park, HJ Park, KH Park, KI Lee

Index: Park, Min-Sup; Park, Hyun-Ja; Park, Koon Ha; Lee, Kee-In Synthetic Communications, 2004 , vol. 34, # 9 p. 1541 - 1550

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Citation Number: 28

Abstract

Abstract The nucleophilic aromatic substitution on 5??chloropyrazoles activated by the electron??withdrawing formyl group offers a useful method to introduce a wide range of N?? containing heterocycles into them. The rate of reaction was greatly affected by the electronic nature of the N??1 substitution.