Tetrahedron

Syntheses of 13 C 2-labelled 11Z-retinals

NJ McLean, A Gansmuller, M Concistre, LJ Brown…

Index: McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D. Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410

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Citation Number: 6

Abstract

To enable solid-state NMR investigations of the rhodopsin chromophore and its photointermediates, a series of 11Z-retinal isotopomers have been synthesised containing pairs of adjacent 13C labels at C9/C10, C10/C11 or C11/C12, respectively. The C9 labelled carbon atom was introduced through the Heck reaction of a 13C-labelled Weinreb acrylamide derivative, and the label at the C12 position derived from a 13C-containing ...

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